Early mobilization after stroke is not associated with cognitive outcome findings from AVERT

TB Cumming; J Bernhardt; D Lowe; J Collier; H Dewey; P Langhorne; AG Thrift; A Green; R Mohanraj; SF Kramer; L Churilov; T Linden

Journal article

Early mobilization after stroke is not associated with cognitive outcome findings from AVERT

TB Cumming, J Bernhardt, D Lowe, J Collier, H Dewey, P Langhorne, AG Thrift, A Green, R Mohanraj, SF Kramer, L Churilov, T Linden

Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018

DOI: 10.1161/STROKEAHA.118.022217

Abstract

Background and Purpose—We aimed to determine whether early mobilization after stroke affects subsequent cognitive function. Methods—AVERT (A Very Early Rehabilitation Trial) was an international, 56-site, phase 3 randomized controlled trial, conducted from 2006 to 2015. Participants were included if they were aged 18+, presented within 24 hours of stroke, and satisfied physiological limits for blood pressure, heart rate, and temperature. Participants were randomized to receive either usual stroke unit care or very early and more frequent mobilization in addition to usual stroke unit care. The Montreal Cognitive Assessment, scored 0 to 30, was introduced as a 3-month outcome during 2008. Resu..

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University of Melbourne Researchers

Julie Bernhardt Author

Leonid Churilov Author

Related Projects (2)

RESEARCH FELLOWSHIP

Stroke affects 1 in 6 Australians and often leads to lifelong disability. This Fellowship will support A/Prof Bernhardt to: 1) complete the ..

AVERT: A large, international, randomised controlled trial testing efficacy and cost effectiveness of early and frequent mobilisation after stroke

AVERT is a large, international clinical trial that tests whether introducing early and frequent exercise helps reduce the unacceptably high..

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by Chest Heart and Stroke Scotland

Awarded by Singapore Health

Awarded by UK Stroke Association

Awarded by UK National Institute of Health Research

Awarded by NHMRC

Awarded by Australia Research Council

Funding Acknowledgements

The trial was initially supported by the National Health and Medical Research Council (NHMRC) of Australia (grant numbers 386201, 1041401). Additional funding was received from Chest Heart and Stroke Scotland (Res08/A114), Northern Ireland Chest Heart and Stroke, Singapore Health (SHF/FG401P/2008), the UK Stroke Association (TSA2009/09), and the UK National Institute of Health Research (Health Technology Assessment Project 12/01/16). NHMRC fellowship funding was provided to Drs Thrift (1042600), Dewey (336102), and Bernhardt (1058635). Dr Bernhardt also received fellowship funding from the Australia Research Council (0991086) and the National Heart Foundation. Dr Linden was awarded an unrestricted grant from STROKE-riksforbundet (Sweden).